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Muhammad Imran Qayyum, Sami Ullah, Umer Rashid, Mater H Mahnashi, Mohammed Merae Alshahrani, Amer Al Ali, Abdulaziz Asiri, Ahmed Abdullah Al Awadh, Osama M Alshehri, Abdul Sadiq
Design, synthesis and preclinical evaluations of (s)-2-((s)-1-benzyl-2,5-dioxopyrrolidin-3-yl)-3-(4-isopropylphenyl)-2-methylpropanal (succ-5) as cardioprotective, hepatoprotective and lipid
In this study, the newly synthesized compound (Succ-5) was analyzed through spectral methods, seen for potential receptor targets via molecular docking, and pre-clinically evaluated for therapeutic effects and safety profile using biochemical and histopathological techniques. The biochemical analysis included assessment of cardiac biomarkers, hepatic enzymes, and lipid profiles, while histopathology included evaluation of cardiac and liver tissues. The toxic dose was determined pre-clinically, f |
2023 |
https://doi.org/10.1016/j.arabjc.2022.104504 |
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Asmat Ullah Khan Shahana Atiq, Hajira, Arshad Mahmood, Syed Uzair Ali Shah, Muhammad Imran Qayyum, Zafar Mohiuddin
Prevalence of Anxiety and Depression in Pregnant Women at Tertiary Care Hospital
Background: Pregnancy is a period of strength and optimism for a woman, even though it is a period of
vulnerability. As many as one in ten new mothers have clinical depression or anxiety before or throughout the first
year after the delivery of a baby, regardless of financial status.
Objective: To evaluate prevalence of anxiety and depression in pregnant women at tertiary care hospital
Methodology: This cross sectional study was carried out at the department of Obstetrics and Gynaecology,
Wom |
2022 |
DOI: https://doi.org/10.53350/pjmhs221611077 |
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Muhammad Imran Qayyum, Sami Ullah, Umer Rashid, Abdul Sadiq, Mater H Mahnashi, Osama M Alshehri, Mohammed M Jalal, Khalid J Alzahrani, Ibrahim F Halawani
Synthesis, Molecular Docking, and Preclinical Evaluation of a New Succinimide Derivative for Cardioprotective, Hepatoprotective and Lipid-Lowering Effects
Cardiac and hepatotoxicities are major concerns in the development of new drugs. Better alternatives to other treatments are being sought to protect these vital organs from the toxicities of these pharmaceuticals. In this regard, a preclinical study is designed to investigate the histopathological effects of a new succinimide derivative (Comp-1) on myocardial and liver tissues, and the biochemical effects on selected cardiac biomarkers, hepatic enzymes, and lipid profiles. For this, an initially |
2022 |
https://doi.org/10.3390/molecules27196199 |
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Sodah Bint Mustafa, Muhammad Akram, Hafiz Muhammad Asif, Imran Qayyum, Asif Mehmood Hashmi, Naveed Munir, Fahad Said Khan, Muhammad Riaz and saeed ahmad
Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and Their Polyherbal Preparation
Background: Diabetes mellitus is a metabolic disorder associated with relative or absolute insulin deficiency or resistance,
characterized by hyperglycemia. Modern prescriptions such as pioglitazone have better therapeutic potential, but its side effects
and financial burden for developing countries have motivated the researchers to find alternative natural drugs to compete
hyperglycemia in patients with diabetes. The present study was conducted to explore the therapeutic potential of selected
m |
2019 |
DOI: 10.1177/1559325819852503 |
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Irum Zulfiqar, H.M. Asif, S. Sultana, M. Akram and Imran Qayoom
IN- VITRO ANTIUREASE ACTIVITY OF AQUEOUS-ETHANOL EXTRACT OF SOME MEDICINAL PLANTS.
Study was planned to evaluate urease inhibitory efficacy of aqueous-ethanol extract of medicinal plants including Mentha piperita, Violo odorata, Trachyspermum copticum, Metricarea chamomileand Foeniculum vulgare, traditionally used for management of gastrointestinal disorders. Phenolhypochlorite method was adoptedto evaluate the urease inhibitory efficacy. The extracts were also phytochemically evaluated. The results showed that aqueous-ethanol extract of Mentha piperita, |
2017 |
http://pjosr.com/index.php/pjs/article/view/181 |
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Muhammad Shoaib Akhtar, Muhammad Imran Qayyum, Nadeem Irshad, Muhammad Yaseen, Abid Hussain, Hamza Altaf, Saif-Ur-Rehman, and Nazir Suleman
Hepatoprotective Properties of methanolic extract of Canscora decussata (Schult) against paracetamol induced liver toxicity in rabbits.
Liver dysfunction is a major health problem. Excessive drug therapy, free radicals, environmental pollutants, and alcoholic intoxicants are the main causes of liver disorders. The present investigation was designed to evaluate its in vivo hepatoprotective properties of Canscorra decussata (family Gentianaceae) whole plant methanolic extract against paracetamol toxicity in rabbits. Hepatoprotective activities of methanolic extracts of C. decussata were examined against paracetamole induced liver |
2015 |
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Yaseen. M. Irshad N. Imran Qayyum M. Kamal Y
Evaluation of antibacterial and cholinomimetic activities of different extracts of Conyza bonariensisIndian
The antimicrobial and cholinomimetic activities of ethanolic and chloroform extracts of Conyza bonariensis plant were investigated. Antimicrobial evaluation of ethanol extract (EE) and chloroform extract (CE) of Conyza bonariensis against 3 strains of microorganisms, using agar well and agar disc diffusion method, revealed their activities against Staphylococcus aureus, Escherichia coli and Sarcina lutea (zone of inhibition: 4-10 mm, 5-16 mm and MIC: 1.33-3 mg/mL, 0.23-1.01 mg/mL, respectively). |
2014 |
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Abid Hussain · Gul Majid Khan · Abdul Wahab · Muhammad Akhlaq · Saif ur Rahman · Hamza Altaf · Naheed Akhtar · Muhammad Imran Qayyum
Potential Enhancers for Transdermal Drug Delivery: A Review
Transdermal drug delivery system (TDDS) aims to deliver the therapeutic moiety via the skin into the systemic circulation for its therapeutic effect. The transdermal route has been recognized as one of the highly potential routes of systemic drug delivery and provides the advantage of avoidance of the first-pass effect, ease of use and withdrawal in case of side effects, and better patient compliance. However, due to resistance of this route is the difficulty of penetration of drug through the s |
2014 |
http://www.ijbmsp.org/index.php/IJBMSP/article/view/59 |
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Muhammad Shoaib Akhtar · Muhmmad Imran Qayyum · Nadeem Irshad · Abdul Malik · Rashid Hussain · Azhar Hussain · M. Yaseen · M. Shafiq
Studies on hepatoprotective properties of different extract of Canscora decussata (Schult) against carbon tetrachloride induced hepatotoxicity
Liver is a vital organ play major role in metabolism and excretion of xenobiotics from the body. Liver injury or liver dysfunction is a major health
problem. The present study was carried out to evaluate the hepatoprotective role of whole plant extracts of Canscora decussata. Hepatoprotective
activities of aqueous and methanolic extracts of C. decussata were examined against carbon tetrachloride induced liver damage in rabbits using
silymarin as control. Enzyme activities of Serum Glutamate O |
2013 |
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Muhammad Shoaib Akhtar · M. Shafiq · Nadeem Irshad · Abdul Malik · Rashid Hussain · M.Imran Qayyum
Assesment of prescribng practices of private GP’S in Islamabad.
The study was conducted to assess the prescribing practices of GP in Islamabad. The purpose of this study is to measure the performance of health.
care providers related to appropriate use of drugs. These indicators basically based on clinical encounters taking place on at outpatient health.
facilities for the treatment of disease. For the purpose of this descriptive quantitative study data from a non-probability sample of 200 patients, 10
patients from each GP, was collected, coded, and anal |
2013 |
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Azhar Hussain · M.Shafiq · Waqas Khawja · Madiha malik · M Imran Qayyum · Nadeem Irshad · M. Nadeem
Management of peptic ulcer in community pharmacies of Pakistan by simulated patient visit.
Peptic ulcer is a common health problem in Pakistan.The study is aimed to evaluate the case management of peptic ulcer at
community pharmacies in Rawalpindi and Islamabad.A comparative cross-sectional study was conducted at 60 community
pharmacies sampled by convenient sampling, 30 from each city. The tool used for this purpose of data collecting is WHO simulated
patient form modified according to objectives. The data was coded, entered and analyzed by using SPSS Version 16. Mann-Whitney
tes |
2013 |
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Nadeem Irshad · Muhammad Shoaib Akhtar · Yousaf Kamal · Muhammad Imran Qayyum · Abdul Malik · Rashid Hussain
Antihyperlipidemic and renoprotective activities of methanolic extract of Canscora decussata extract in alloxan-induced diabetic rabbits.
The current study was designed to evaluate the hypolipidemic and renopro-tective effects of methanolic extract of powdered Canscora decussata whole plant in the diabetic rabbits. Thirty rabbits were divided into five groups having 6 animals each including normal and diabetic controls groups, the remaining groups received methanolic extract in 400 and 600 mg/kg doses and another group got pioglitazone (3 mg/kg) for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-ch |
2013 |
https://doi.org/10.3329/bjp.v8i3.15506 |
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Muhammad Shoaib Akhtar · Abdul Malik · Nadeem Irshad · Ghulam Abbas · M Imran Qayyum · Yousaf Kamal
Modulatory effect of Canscora decussata (Schult) on hematological parameters in alloxan induced diabetes model.
The present study was designed to assess the effect of methanolic (M) extract of Canscora decussata on hematological parameters in alloxan-induced diabetic rabbits for duration of one month.(M) extract significantly (P< 0.001) increase RBCs, PCV, MCV, MCHC, Hb level, total leucocytes count (TLC), neutrophil and platelet count of the treated diabetic rabbits as compared to the diabetic control group. The extract produced no significant change in Eosinophil, Lymphocyte and Monocyte count. The curr |
2012 |
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